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Why Can’t Humans Breed with Animals?

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Why can’t humans mix with animals? What happens to our DNA that makes us incompatible?
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Sources for this episode:
https://genetics.thetech.org/ask-a-geneticist/why-dogs-and-people-cant-have-babies
https://en.wikipedia.org/wiki/Reproductive_isolation
http://www.slate.com/articles/news_and_politics/explainer/2006/11/humanderthals.html

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